Research Articles
The Cellular Recycling Center: How Protein Degradation Governs Health and Disease
Explore the ubiquitin-proteasome system, its role in protein degradation, connections to human diseases, and revolutionary therapeutic approaches like PROTAC technology.
Cellular Sabotage: How Hybrid Molecules Are Revolutionizing Breast Cancer Treatment
Discover how hybrid small molecules like SNIPER(ER) are transforming breast cancer treatment by inducing degradation of estrogen receptor-alpha and triggering necrotic cell death.
The Cell's Master Janitor: How a Tiny Tag Dictates Life and Death in Your Cells
Explore the fascinating ubiquitin system - the molecular cleanup crew that controls protein degradation and regulates the cell division cycle through precise tagging mechanisms.
Controlling the Cosmos Within: The Water-Soluble Wonder Revolutionizing C. elegans Research
Discover how water-soluble synthetic auxin analog K-NAA enables precise protein degradation in C. elegans research, revolutionizing developmental biology studies.
The Cellular Cleanup Crew: How Protein Recycling Failures Drive Parkinson's Disease
Explore how the ubiquitin-proteasome system functions as cellular cleanup crew and its crucial role in Parkinson's disease pathology and potential treatments.
Cellular Housekeeping: How Scientists Decode the Protein Recycling System
Discover how scientists use proteogenomics to decode degrons - the molecular tags that control protein degradation in cells, with implications for cancer treatment and neurodegenerative diseases.
SNIPER(ER): The Molecular Assassins Revolutionizing Breast Cancer Treatment
Explore how SNIPER(ER) molecules target and degrade ERα proteins in breast cancer treatment through innovative protein degradation technology.
Taming the Gatekeeper: Hijacking Cellular Scrap to Rebuild Our Body's Nuclear Border
Explore how chemically induced nuclear pore complex protein degradation via E3 ligase TRIM21 is revolutionizing cellular biology and potential therapies.
The Cellular Cleanup Crew: How Degronopedia Is Cracking the Code of Protein Disposal
Explore how DEGRONOPEDIA is revolutionizing protein degradation research through systematic degron discovery and analysis.
The Cell's Demolition Crew: How Scientists Are Teaching Our Bodies to Destroy "Undruggable" Proteins
Discover how the groundbreaking PROTINb platform uses targeted protein degradation to eliminate previously 'undruggable' proteins causing diseases like cancer and neurodegenerative disorders.